How AI, GLP-1s and de-globalisation are reshaping growth, value and quality

Unsplash - 24/06/2026

AI, GLP-1s and de-globalisation are reshaping sector dynamics and challenging traditional growth, value and quality classifications. Christopher Lees, Senior Fund Manager of the JOHCM Global Select Fund, considers the implications for portfolio construction and equity investing.

Artificial Intelligence (AI), weight-loss therapeutics (GLP-1), and de-globalisation are rewiring global macroeconomic frameworks, disrupting many industries, and altering the foundation of corporate profits. This is driving significant stock dispersion within the traditional equity factors of growth, value and quality, making them misleading and less useful to investors.

The winners and losers from AI, GLP-1 and de-globalisation have made some parts of the traditional growth universe resemble value stocks; some parts of the traditional value universeย resemble growth stocks; and many traditional quality stocks are seeing their previously solid business models fundamentally challenged.

AI

AI is not just a tech-sector phenomenon, it is reshaping many industries by driving massive capital expenditure into the physical economy while disrupting many traditional business models.

The economic impact is highly uneven, creating winners who boost productivity across allย sectors, and losers who fail to secure a return on their AI investments or get left behind. AI is likely to have aย similar impact on many industries as Amazon had on retail, disrupting incumbents, compressing margins, and forcing businesses to reinvent themselves or risk irrelevance.

GLP-1

The rapid adoption of GLP-1 weight-loss drugs represents a massive, idiosyncratic lifestyle and consumer behaviour shift. By altering consumption patterns, these therapeutics are challenging traditional consumer staples and healthcare businesses, while simultaneously expanding opportunities in specialised wellness, fitness, nutrition and healthcare service providers.

Perhaps the greatest irony of the GLP-1 revolution is that Novo Nordisk, the company that sparked it, now looks more like a value stock than a growth stock. Despite operating in one of the fastest-growing segments of global healthcare, a series of management mistakes has left investors questioning whether the companyโ€™s growth potential is being fully realised.

De-globalisation

The shift from globalised, just-in-time supply chains towards more resilient, onshored, just-in-case production models has increased business costs and challenged the long-term profitability assumptions underpinning some multinational companies.

Yet, this structural realignment is also creating significant domestic investment opportunities. As governments increasingly prioritise economic security, they are directing capital towards domestic infrastructure, energy independence and strategic industries, often supported by local financing channels.

At the same time, access to critical commodities is becoming a matter of national security rather than simple economic efficiency. In this environment, selectedย financials, industrials and commodity producers should no longer be viewed solely as traditional value stocks; they are emerging as beneficiaries of powerful long-term growth trends.

Challenges vs opportunities: growth, value, quality

As a result, the traditional boundaries between growth, value and quality investing are becoming increasingly blurred, as AI, GLP-1s and de-globalisation reshape earnings growth expectations across industries and geographies. It makes sense to us that the traditional definitions of growth, value and quality are being challenged.

Our process is based upon our belief that share prices tend to follow (or lead) changing earnings growth expectations, not labels.ย 

Growth

The definition of growth is always changing, just ask the horse, the canal, the railroad, the car, the plane, and the recently IPOโ€™d SpaceX. The early stages of the AI boom created a hardware arms race, in which the previouslyย โ€œcyclical growthโ€ semiconductor sector became perceived as a โ€œstructural growthโ€ sector.

As the AI investment boom matures, the market will probably remember that semiconductors are cyclical and pivot to adjacent AI growth sectors. So far, many leading AI companies have stayed private for much longer than usual, starving the public equity markets of their growth.

This will soon change with the anticipated trillion-dollar IPOโ€™s of Anthropic and OpenAI, which will all become new and large parts of the growth index, following SpaceX

Value

The definition of value is changing. Japan used to be one of the most expensive developed equity markets and currencies in the world; now it is one of the cheapest.ย Today, the software and consumer staples sectors are well on their way to becoming the new value sectors due to disruption from AI and GLP-1s, respectively.

Meanwhile,ย de-globalisation, onshoring and government-backed infrastructure spending are boosting traditional value sectors such as financials, industrials, materials, and utilities. These legacy businesses are not relics of the past; they are helping build the infrastructure of the future.ย 

Perhaps investors need a new acronym: VARG = Value at the right growth, in place of GARP. After all, when valueย stocks become growth stocks, the labels matter far less than the earnings.

Quality

Even the definition of quality is changing. Kodak was once considered a textbook quality stock, generating attractive and dependable returns. Then digital cameras arrived, its competitive moat disappeared, and the business collapsed. Todayโ€™s quality companies may not be tomorrow’s.

Many software companies used to be quality businesses, but then came AI. Snacking used to be a quality business, then came GLP-1s. Manufacturing in low-cost countries and selling in high-cost countries used to be a quality business model, then came China, Tariffs, and de-globalisation.

After the European financial crisis, nobody thought of European banks as quality businesses as their return on equity collapsed to near zero.

Today, you might beย surprised to learn that the MSCI European Bank index has a higher return on equity than the MSCI USA bank index (13% and rising, versus 12% and not rising) with less private credit issues. The worm has turned as they say, and when the facts change, we change.

In summary, AI, GLP-1s and de-globalisation are changing where investors find growth, value and quality because they are changing future earnings expectations.

As these forces create new winners and losers, traditional style labels are becoming less informative. Rather than asking whether a stock is growth, value or quality, investors should ask whether earnings expectations are improving or deteriorating. Ultimately, it is changing earnings, not style labels, that drive stock returns.

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